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カタログ番号	製品名	別名	ターゲット
T76115	Pyruvate kinase
	Pyruvate kinase is a glycolytic enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP [1] .
T12499	PKR-IN-2		PKM
	PKR-IN-2 is a activator of pyruvate kinase (PKR).		PKM
T6816	DASA-58		PKM
	DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.		PKM
T4223	Mitapivat	PKR-IN-1	PKM
	Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.		PKM
T11765	KPLH1130		Dehydrogenase , PDK
	KPLH1130, a specific pyruvate dehydrogenase kinase (PDK) inhibitor, enhances glucose tolerance in mice fed a high-fat diet (HFD). It effectively hinders macrophage polarization and mitigates proinflammatory reactions.		Dehydrogenase , PDK
T17224	VER-246608		Dehydrogenase , PDK
	VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism an...		Dehydrogenase , PDK
T2447	AZD7545		Dehydrogenase
	AZD7545 is a potent PDHK inhibitor.		Dehydrogenase
T22350	JX06		Apoptosis , Dehydrogenase , PDK
	JX06, a potent, selective and covalent PDK inhibitor, inhibits PDK1, PDK2 and PDK3 with IC50 of 49 nM, 101 nM and 313 nM respectively.		Apoptosis , Dehydrogenase , PDK
T7214	TEPP-46	ML265	PKM
	TEPP-46 (ML265) is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation and size in a mouse xenograft model. .		PKM
T4170	PKM2-IN-1	PKM2 inhibitor,compound 3k	PKM
	PKM2-IN-1 (compound 3k) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.		PKM
T12412L	PDK4-IN-1 hydrochloride		Apoptosis , PDK
			Apoptosis , PDK
T19783	Dehydroabiethylamine	NSC-2955,NSC 2955,Dehydroabietylamine,NSC2955,Leelamine free base,Leelamine	P450 , PDK
	Dehydroabiethylamine (NSC-2955) is an inducer of hepatic CYP2B activity. Dehydroabiethylamine inhibits pyruvate dehydrogenase kinases (PDKs) and intracellular cholesterol transport with anti-tumor activity.		P450 , PDK
T0745	Disodium monofluorophosphate	Sodium Monofluorophosphate,NSC248	Phosphatase , PKM , Phosphorylase
	Disodium monofluorophosphate (NSC248) is a competitive inhibitor of pyruvate kinase and alkaline phosphatase, which also irreversibly inhibits phosphorylase phosphatase.		Phosphatase , PKM , Phosphorylase
T67900	PKM2 inhibitor G		PKM
	PKM2 inhibitor G is a inhibitor of pyruvate kinase.		PKM
T15944	M77976		PDK
	M77976 is a selective ATP-competitive inhibitor of pyruvate dehydrogenase kinase 4 (PDK4) with an inhibitory effect on PDK4, having an IC50 value of 648 μM. It is used for research related to obesity and diabetes.		PDK
T60102L	Dimethylaminomicheliolide HCl		PKM
	Dimethylaminomicheliolide HCl has potential anti-inflammatory and anti-tumor activity and inhibits the proliferation of glioblastoma cells by targeting pyruvate kinase 2 (PKM2) and reconnecting aerobic cell populations.		PKM
T62758	PKM2 activator 2		PKM
	PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activator with an AC 50 value of 66 nM.PKM2 activator 2 has anti-tumor proliferative properties and attenuates the Warburg effect by normalizing cellular glycolytic metabol...		PKM
T15362	FX-11	LDHA Inhibitor FX11	Dehydrogenase
	FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce...		Dehydrogenase
T69865	Mitapivat sulfate
	Mitapivat sulfate, also known as AG-348 sulfate hydrate, is an allosteric activator of Pyruvate Kinase (PK) that may be useful in the treatment of Pyruvate Kinase Deficiency.
T70665	PF-06284674
	PF-06284674 is a cell permeable, potent and selective M2 isoform of pyruvate kinase (PKM2) activator.
T69677	Mitapivat sulfate anhydrous
	Mitapivat sulfate anhydrous is an allosteric activator of Pyruvate Kinase (PK) that may be useful in the treatment of Pyruvate Kinase Deficiency.
T12498	PKR activator 2		Others
	PKR activator 2 is a potent activator of pyruvate kinase-R (PKR).		Others
T39753	Etavopivat	FT-4202
	Etavopivat is a powerful, specific, orally bioavailable activator of pyruvate kinase (PKR) in red blood cells (RBCs). It exhibits potent properties against sickling.
T12412	PDK4-IN-1		Others
	PDK4-IN-1 is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4)(IC50 value of 84 nM).		Others
T12497	PKR activator 1		Others
			Others
T70418	TLN-232
	TLN-232, also known as CAP-232, is a synthetic cyclic heptapeptide with potential antineoplastic activity. Pyruvate kinase (PK) inhibitor TLN-232 targets pyruvate kinase M2 (M2PK), which may disrupt tumor cell anaerobic ...
T71867	PKM2 inhibitor 2825-0090
	PKM2 inhibitor 2825-0090 is a Novel pyruvate kinase M2 (PKM2) inhibitor, reducing tumor growth of NSCLC xenografts in vivo.
T74024	2,5-Anhydro-D-glucitol-1,6-diphosphate
	2,5-Anhydro-D-glucitol-1,6-diphosphate acts primarily as a moderate stimulant of yeast Pyruvate Kinase and serves as an analog to the a-form, 2,5-anhydro-D-mannitol 1,6-bisphosphate, which is a potent allosteric activato...
T75132	PKR activator 4
	PKR activator 4 (example 7A), a potent activator of pyruvate kinase R (PKR), holds promise for blood disorder research [1].
T68986	ZINC08383544
	ZINC08383544 is a specific pyruvate kinase M2 activator which promotes the formation of PKM2 tetramer. ZINC08383544 effectively blocks PKM2 nuclear translocation, and inhibits the growth of tumor.
T63012	TM-1
	TM-1 is a potent pyruvate dehydrogenase kinase (PDHK) inhibitor that inhibits the activity of PDHK1 (IC50: 2.97 μM) and PDHK2 (IC50: 5.2 μM). TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation and inhibits...
T60527	PDHK-IN-3
	PDHK-IN-3 (compound 7) is a potent inhibitor of pyruvate dehydrogenase kinase(PDHK) with IC50s of 0.21 and 1.54 μM for PDHK2 and PDHK4, respectively [1].
T74830	PDK-IN-1
	PDK-IN-1 (compound 7o), a pyruvate dehydrogenase kinase (PDK) inhibitor, exhibits IC50 values of 0.03 and 0.1 μM against PDK1 and HSP90, respectively. This compound effectively targets the PDH/PDK axis, significantly red...
T74128	NCGC00188636
	NCGC00188636, a novel covalent pyruvate kinase (PYK) inhibitor, obstructs nucleotide binding to PYK's active site, rendering it instrumental for research into the metabolism across various organisms and cell types.
T81788	Mito-SilylDCA
	Mito-SilylDCA, a mitochondrial-targeted pyruvate dehydrogenase kinase (PDK1) inhibitor, possesses a thiamine pyrophosphate (TPP) moiety for PDK1 targeting within the mitochondrial network, several dichloroacetate (DCA) g...
T73525	ML202
	ML202 is a highly specific allosteric activator of human pyruvate kinase M2 (hPK-M2), enhancing the cooperativity of phosphoenolpyruvate (PEP) binding, with negligible effect on adenosine diphosphate (ADP) binding.
T72663	(Rac)-Etavopivat	(Rac)-FT-4202
	(Rac)-Etavopivat ((Rac)-FT-4202), an isomer of Etavopivat, is an orally active activator of erythrocyte pyruvate kinase-R (PKR) used in studies related to sickle cell disease and other haemoglobinopathies [1].
T79637	CIAC001
	CIAC001, a pyruvate kinase PKM2 inhibitor, exhibits anti-neuroinflammatory properties. It effectively suppresses LPS-induced production of proinflammatory nitric oxide (NO) and provides protection to immunologically acti...
T37355	CAY10703
	Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria. Inhibition of PDHK shifts cell metabolism from glycolysis ...
T38357	1,3,6,8-Pyrenetetrasulfonic Acid (sodium salt hydrate)
	1,3,6,8-Pyrenetetrasulfonic acid is an intermediate in the synthesis of the color additive pyranine.1It has been used to stabilize intermolecular interactions for the crystallization ofL. mexicanapyruvate kinase.2 1.Jiti...

Compounds

Target: Dehydrogenase, PDK

VER-246608

T17224

Synonym:

Target: Dehydrogenase, PDK

AZD7545

T2447

Synonym:

Target: Dehydrogenase

JX06

T22350

Synonym:

Target: Apoptosis, Dehydrogenase, PDK

Synonym: PKM2 inhibitor,compound 3k

Target: PKM

PDK4-IN-1 hydrochloride

T12412L

Synonym:

Target: Apoptosis, PDK

Dehydroabiethylamine

T19783

Synonym: NSC-2955,NSC 2955,Dehydroabietylamine,NSC2955,Leelamine free base,Leelamine

Target: P450, PDK

Disodium monofluorophosphate

T0745

Synonym: Sodium Monofluorophosphate,NSC248

Target: Phosphatase, PKM, Phosphorylase

Dimethylaminomicheliolide HCl

Synonym: LDHA Inhibitor FX11

Target: Dehydrogenase

Mitapivat sulfate anhydrous

PKM2 inhibitor 2825-0090

T71867

Synonym:

Target:

2,5-Anhydro-D-glucitol-1,6-diphosphate

Synonym: (Rac)-FT-4202

1,3,6,8-Pyrenetetrasulfonic Acid (sodium salt hydrate)

T38357

Synonym:

Target:

カタログ番号	製品名	別名	ターゲット
T0809	Dicoumarol	Dicumarol	Dehydrogenase , NADPH , PDK
	Dicoumarol (Dicumarol) is a hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicoumarol is a competitive inhibitor of vitamin K epoxidereductase; t...		Dehydrogenase , NADPH , PDK
T3604	Sodium dichloroacetate	Sodium Dichloroacetate,DCA,bichloroacetic acid,Sodium dichloroacetate (DCA)	Apoptosis , Dehydrogenase , Reactive Oxygen Species , PDK
	Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion chann...		Apoptosis , Dehydrogenase , Reactive Oxygen Species , PDK
T1125	Shikonin	NSC 252844,Isoarnebin 4,(+)-Shikonin,Alkanna Red,C.I. 75535,Anchusa acid	TNF , NF-κB , Chloride channel , HIV Protease , PKM
	Shikonin (Anchusa acid) is a natural product, a TMEM16A chloride channel inhibitor (IC50=6.5 μM) and selective PKM2 inhibitor. Shikonin exhibits antitumor, anti-inflammatory and wound healing activities.		TNF , NF-κB , Chloride channel , HIV Protease , PKM
T8363	DL-Serine		PKM
	DL-Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.		PKM
T4898	Potassium 1-carboxyvinyl hydrogenphosphate	PEP-K,Phospho(enol)pyruvic acid monopotassium	Others , Endogenous Metabolite
	Potassium 1-carboxyvinyl hydrogenphosphate (PEP-K) is involved in glycolysis and gluconeogeneis. In glycolysis, PEP is metabolized by Pyruvate Kinase to yield pyruvate. In plants, PEP is involved in the formation of arom...		Others , Endogenous Metabolite
T5213	Acetyl phosphate(lithium potassium)	Lithium potassium acetyl phosphate,Acetylphosphoric acid	Others , Endogenous Metabolite
	Acetyl phosphate lithium potassium (Lithium potassium acetyl phosphate) is a compound involved in taurine and hypotaurine metabolism as well as pyruvate metabolism. Acetyl phosphate lithium potassiu is generated from sul...		Others , Endogenous Metabolite
T60581	Alkannin
	Alkannin is a potent and specific tumor-specific pyruvate kinase-M2 (PKM2) inhibitor that does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin is a potential anticancer agent [1].
T16837	SAICAR		Others
			Others

天然物製品

Dicoumarol

T0809

Synonym: Dicumarol

Target: Dehydrogenase, NADPH, PDK

Sodium dichloroacetate

T3604

Synonym: Sodium Dichloroacetate,DCA,bichloroacetic acid,Sodium dichloroacetate (DCA)

Target: Apoptosis, Dehydrogenase, Reactive Oxygen Species, PDK

Shikonin

T1125

Synonym: NSC 252844,Isoarnebin 4,(+)-Shikonin,Alkanna Red,C.I. 75535,Anchusa acid

Target: TNF, NF-κB, Chloride channel, HIV Protease, PKM

Potassium 1-carboxyvinyl hydrogenphosphate

T4898

Synonym: PEP-K,Phospho(enol)pyruvic acid monopotassium

Target: Others, Endogenous Metabolite

Acetyl phosphate(lithium potassium)

T5213

Synonym: Lithium potassium acetyl phosphate,Acetylphosphoric acid

Target: Others, Endogenous Metabolite

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-04445	PDK4 Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus Insect Cells
	Pyruvate dehydrogenase kinase 4 (PDK4) is a mitochondrial protein that regulates the TCA cycle.PDK4, a vital mitochondrial protein, controls the switch between glycolysis and oxidative phosphorylation based upon nutrient...
TMPY-04568	PDK1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Pyruvate dehydrogenase kinase, isozyme 1, also known as [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial and PDK1, is a member of the PDK / BCKDK protein kinase family. PDK-1 is expressed predominantl...
TMPY-04765	PKLR Protein, Human, Recombinant (His)	Human	E. coli
	Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. Pyruvate kinase deficiency (PKD) is the most frequent red blood cell enzyme abnormality of the glycolytic pat...
TMPY-04766	PKM2 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus Insect Cells
	PKM2 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 60 kDa and the accession number is P52480-2.
TMPY-04465	PKM2 Protein, Human, Recombinant (His)	Human	E. coli
	PKM2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 59 kDa and the accession number is P14618-1.
TMPJ-00955	MDH1 Protein, Human, Recombinant (His)	Human	E. coli
	Malate Dehydrogenase, Cytoplasmic (MDH1) is an enzyme which belongs to the MDH Type 2 sub-family of LDH/MDH superfamily. MDH1 is involved in the Citric Acid Cycle that catalyzes the conversion of Malate into Oxaloacetate...